SWOG 9007 - "Cytogenetic Studies in Leukemia Patients"

Treatment Plan    (Supplied Drug:  None)

It is suggested that specimens collected for this protocol be taken from the diagnostic procedure, to prevent the need for an additional post-diagnostic specimen collection for registration.

Pts will receive tx as directed by the tx protocols on which they are registered. Institutions will submit specimens of bone marrow or peripheral blood to a SWOG-approved cytogenetics laboratory. Objectives are:

1) Estimate frequencies and prognostic significance of cytogenetic abnormalities in marrow or blood cells of leukemia pts prior to tx on SWOG protocols and at various times in the course of tx.
2) Estimate correlations between the presence of cytogenetic featues and of clinical, pathophysiological, cellular, or molecular characteristics in these pts.
3) Provide quality control for SWOG cytogenetic data.

Submit:

1)  2-3cc bone marrow aspirate for cytogenetics (draw in heparin-coated syringe & send in sodium heparin green-top tube)

2)  5-7cc perip blood (only send if not a good BM aspir or is questionable)

Eligibility

• Registered to SWOG 8326, 8600, 8612, 9034, 9108, or any new SWOG leukemia protocol approved as of 1990.
• Signed informed consent and date of IRB approval.
• Specimens to be submitted to Linda Cooley, MD; Children's Mercy Hospital Cytogenetics Lab; Kansas City, MO.  Contact KCCOP for laboratory packing/shipment instructions.